Increasing age, especially after 65 (or after 50 if you have risk factors for atherosclerosis)Ĭomplications of peripheral artery disease caused by atherosclerosis include:.High levels of an amino acid called homocysteine, which increase the risk for coronary artery disease.A family history of peripheral artery disease, heart disease or stroke.Smoking or having diabetes greatly increases the risk of developing peripheral artery disease.Other things that increase the risk of peripheral artery disease include: Less common causes of peripheral artery disease include: When it occurs in the arteries supplying blood to the limbs, it causes peripheral artery disease. It reduces blood flow through the arteries.Ītherosclerosis affects arteries throughout the body. Peripheral artery disease is often caused by a buildup of fatty, cholesterol-containing deposits (plaques) on artery walls. Plaque and blood clots can reduce blood flow through an artery. ![]() If a plaque ruptures, a blood clot can form. Plaque can cause an artery to become narrowed or blocked. If there's too much cholesterol in the blood, the cholesterol and other substances may form deposits called plaque. When to see a doctorĬall your health care provider if you have leg pain, numbness or other symptoms of peripheral artery disease. Hanging the legs over the edge of the bed or walking may temporarily relieve the pain. If peripheral artery disease gets worse, pain may occur during rest or when lying down. Hair loss or slower hair growth on the legs.Pain when using the arms, such as aching and cramping when knitting, writing or doing other manual tasks.Sores on the toes, feet or legs that won't heal. ![]()
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